[ badly slurred] This is Tom and it’s the 20th of August around 10 after 12:00 AM And this is me reading this [badly slurred] Belonging [badly slurred] to the Y [badly slurred] Strengthens Communities and Two hours later, this is how I talk now Notice how my mouth seems to be moving a whole lot less. There’s no straining.There’s no spasming big change from the”[goofy voice] “oh I can’t talk man” man So there’s something in the ingredients in ambien that allow me to speak and relax and You know I can actually talk like a normal person which is great Ambien is a drug with many faces and not all of them are sleeping best known for treating Insomnia causing bouts of uncontrollable nocturnal binge eating and endowing Tiger woods with enhanced sexual abilities Ambient has another property one that may very well change medical history by normalizing neurological functioning and damage to brains in 1996 24 Year-Old Louie V owen was struck by a truck resulting in an injury that left him in a persistent vegetative state then in 1999 Louie’s mother decided to feed her unconscious son a crushed ambien tablet through a straw to reduce Involuntary muscle spasms in his arms to her amazement Louis spontaneously regained consciousness opening his eyes and speaking for the first time in 3 years and So I decided to visit Louie in South Africa and learn more about the ambient effect I met with Dr.. Walley Nel who has known Louis since he was a child and saw Louie through his zolpidem metamorphosis is me Louie VC, Saw Left man.
Hahaha look on this! [foreign language] Do you know that you? Were the first person in the whole world That took this soul knocks Yes, what still work? Oh? Yes, oh yes, it’s still working that was the picture how he looked before his accident Louie was 25 years old and he was working at the Far Eastern hospital as Switchboard operator, and he borrowed a bicycle from one of the frames thing and that knotted about how post 11 He somebody was outside market, and they were calling me there was an accident a bicycle accident so they took me through to the ICU and he was lying there But his head was twice as big as it used to be cause he was brain damaged. It was terrible you know for For a mom, to see your son like that
that’s bad. New Year’s in the solid coma he never said one single word nothing He swallowed the tablet and we were staying here myself and my husband and I think it was after 20 minutes I Just heard things he didn’t say anything he just did the- did the “mmm” this Like in the past but I said I said sweetheart something and he said “Bareyne, it’s nothing” and after about 40 minutes He’s asked for life. You know love stars It was like twinkling and I said “Louis can you hear me?” then all of a sudden he says “yes” He says yes, hello, Mommy andI couldn’t believe and I couldn’t I just cried and I phoned up to Wally and I’ve heard my family said Louie can talk! She told me the story. I said it’s totally impossible this doesn’t happen these things in my time The Brain is dead it’s dead. So I came out on the Sunday. We gave him the tablet and I went to stand there me and the family was standing down the bed I saw also the twinkle in the eye, then you started with all your monsters then!
hMM He is a rehabilitation Louie had these three tablets a day He’s on half twice a day now his Iq 10 o’clock before he gets his tablet is 70 and After the tablet two hours after the half his IQ goes up to 90 what other sorts of brain injuries could be treated with Ambien what we have treated [and] what we are treating as multiple sclerosis a Dementia Alzheimer’s cerebral palsy near drownings We’ve got the problem. We’ve got the answer But we haven’t got the in-between We didn’t know we didn’t know where to start or how to start until the Ralphie is the big fun be honest on That one there on the explanation part on the more scientific ornament In 1999 Ralph Klaus stumbled upon an article about the miraculous awakening of Louis Vienne and decided he wanted to study the effect further by imaging changes in cerebral Perfusion before and after ambien What happened in Louis’ Brian Was that the way these big areas that weren’t functioning at all were kind of dark areas and then after zolpidem These regions all normalized so like a day/night difference This this is Louis’ brain his original state before was operative and you can see this large decreased uptake in the Parietal region which Normalizes after zolpidem and see with error is there [three] it’s about forty percent of normal comes to A hundred percent after zolpidem. So you have these two phenomena. You have the excited toxic effect Which is the same time destabilizing the micro environment say I was almost is suicide cells that offer themselves for the greater good and you have the other cells which are influenced by the GABA which don’t regulate and survive.
The exact Biochemical mechanism of ambience therapeutic effect in Brain injury has yet to be identified But Dr. Klaus theorizes the GABA-A ion channel Undergoes an epigenetic change after brain trauma Causing an unregulated influx of chloride ions that suppress neuronal activity so you have really two different Gaba-a receptors here you’ve got the normal gaba receptors which you know it induces the sort of sleepy change then you have the abnormal receptors Which has gone through all these these phrases after brain injury is not the same as this original receptor anymore It is a receptor.which is super sensitive and Zolpidem through distorting this receptor normalizes it again and when that happens Then the brain becomes less suppressed obviously and you see these changes on the brain spect scan or metabolic [tells] and you see the changes, Clinically, so Something works anywhere in this in this in this spectrum, basically Because every way in the spectrum you have you have this this part that is Damaged, dead if you like, all non-Reversible injury if you like And you’ve got this parallel area of dormancy This is Jonathan pool. He’s a bank manager here in Guildford actually and He had a stroke And after the stroke he had problems understanding people music suffers from auditory diagnosis her so he hear sounds and hears words But he doesn’t know what they mean Dr.. Klaus, and I went to meet Jonathan Poole the banker who lost his numbers a Sudden stroke at the age of 56 left pool with a lesion in his left temporal lobe That interfered with his ability to read and understand language Dr.. Klaus Prescribed pool Zolpidem and I wanted to see the effects firsthand See I can hear what you’re saying very well But if Klaus talked to me, I would not have half of what saying Because this this ear is Doing something funny inside the brain So so when I talk to it like that, I talk quite well But right here from this word my words will come very short the [ceiling] [oh] Interesting and if you see Dr.. Klau’s lips while he speaks are you then able to interpret the words? Most of it, but it’s a new word like names numbers People Don’t hear and this is written down in front of me that I might have a chance to say it See took me nearly Six months to hear my wife’s name which is Sue or Susan but it was someone on the phone and just give a name of sue It’s all it guh That means no name to me at all It’s been very much more easy since he’s been under zolpidem. I wouldn’t let anyone take him off it I really wouldn’t because it makes life so much easier for us all But before his stroke Jonathan was very articulate. It was very good with figures [and] things like that Since his stroke although he can obviously now speak properly. He does still have problems with words He very bad with numbers particularly over the telephone so quite often if he gives me a message over the phone I know I have to check it first because it’s quite possible. He’s got the words wrong numbers wrong Could we test the effect Dr.. Klaus would you? Write down a few numbers Just sort of more of this complex numbers if it’s a give you five numbers right and then you You say them once I say them. I said yes, you know your videos often an hour later. We do the sentence. Yes now He will see something Possible, okay you ready. Yes 583 153 613 377 Something some 291 250..250..251 830 th.. three and I’ve lost it. I had I think I think I had three but I’ve lost I didn’t hear it quickly enough So that one I’ve lost that one yeah 991 171 okay, we asked you five questions and five were wrong. Yeah [Laughing] Let’s get your favorite item right oh Even though Jonathan Poole had already taken one ten milligram ambien that morning the effects had diminished by the time we arrived So he asked him to take a second allowed 60 minutes for the drug to Reach optimal Concentrations and tested him again to see if his understanding of numbers had improved 641 6-4-1 198 1-9-8 472 4-7-2 Seeing the positive effects of Ambien on pool and Louie was extremely impressive But there was still the matter of Thomas Rowe a voice-over artist. Who’s one of the most dramatic responders to the ambient effect “that was fun!” In 2009 Rowe played a tragic visit to the dentist one that left him without a wisdom tooth and without the ability to speak or Rowe’s career was ruined and he was forced into retirement at the age of 52 One night. He stayed awake on Ambien to find his voice Had returned this is how I talk now [and] so I traveled to Orlando, Florida to meet Tom at his former studio Sunspots I Spent an hour years here. I was the voice of The circuit city when they were in business for six years I did a lot of Nissan, uh.. “It all ends tomorrow!” That kind of stuff. When I hear myself or feel myself speak it’s hard I sit, it’s hard to believe Ya know? Oh, it was like a country song I lost my career, and then my dog died and what can I do other than if there was a job for someone with a speech disorder It’s not so much. I I want to go back behind the Mic again But I would like to speak without pain, ’cause it really hurts. For someone that hasn’t experienced anything like this could you describe it feels like muscularly? if you took your bottom lip and Pulled it hard maybe as hard as you could out and then took your neck and grab that and pull it back The forehead and pulled up And your cheeks and pull back And I feel everything thing Turlock only Drug the work is handy in order to test ambience therapeutic effect [I] Asked Tom to promote a Chevy spring event the [GMS] Every spring of that. I’m more patient $8,000 off or next Tahoe [lure], I can hear me And the inside me Breathing that I know the rhythm I know the sound Drives me.. unlike many brain Trauma patients who don’t experience ambience typical hypnotic effect tommrow started to become inebriated In a world of giant monkeys only one man will stand above the apes tonight on WGN and Will need to arm them with the skills the knowledge and the confidence they need to be victorious Yeah, that’s pretty good. Yeah. He’s funny. Can’t deny them in his It’s working yes, it’s not there yet it’s working while General Grant was busy with his horses there was something going on Deeper in the South… the sun had set and although Tom had to fight a strong urge [to] sleep his voice was back and Couldn’t be stopped. It’s Mardi gras at Universal studios. Who are you gonna? Love it [cher] we’re gonna have a big [time] Yeah that’s no different than what was done when I was there and now with the ambien in full effect [I] once more asked Tom to promote a Chevy spring event It’s the [gene] Messer Chevy spring event and we’re taking 8,000 dollars off your next tahoe. That’s right get a Brand-new 2010 Chevy tahoe at Jean Messer Chevrolet, and we’ll take $8,000 off MsRP. It’s time for our new Chevy Tahoe from Jean Messer Chevrolet Wow, wow, it feels like being Alive when I do that Don’t do that cause [ooh], [hahaha] What started out as a serendipitous discovery may now represent one of the most important interventions for brain Trauma? with time and medical research who knows what the future may hold We try to push along this research on zolpidem all the research that you do is actually just art of interest in Goodwill of Of people who are trying to find out what’s going on? It’s just scientific curiosity really these Insomnia tracks are not optimized for pattern of brain damage and therefore there is a lot of money to be made but if people develop this and optimize it specifically for for people with brain damage Now for myself getting on it’s it’s such a wonderful thing. [how] can we leave [it]? I don’t think it’s fair to any Anybody or any population or any race or anything to say leave it with what we’ve gone [through] now you